Curodont^TM Repair
Fluoride Plus

Curodont Repair Fluoride Plus is a non-invasive restorative treatment for the in-office drill-free management of early-stage caries on all tooth surfaces. It stops the progression of the treated lesions and enables the restoration of mineral density throughout the depth of lesions. 

Curodont™ Repair Fluoride Plus is designed to treat early‑stage caries, including white spot lesions, by enabling the penetration of fluoride together with the patient’s own salivary phosphate and calcium ions beyond the tooth surface and into the full depth of the lesion. 

This supports a biomimetic process of fluoride‑enhanced hydroxyapatite crystal formation, which goes beyond prevention with traditional fluoride‑based products and enables the restoration of damaged enamel throughout the lesion. 

This process not only stops the further progression of tooth decay, but also promotes the formation of enamel crystals throughout the entire depth of the lesion. As a result, it helps preserve natural tooth structure and supports the restoration of mineral density of the early-stage caries, without the need for injections and restorative procedures. 

This represents a significant breakthrough in cavity management, closing a long‑standing treatment gap in care and establishing a new category of drill‑free restoration of early-stage caries when traditional prevention has failed. 

Machiulskiene V et al. in a consensus report in 2020 stated that “remineralization is the net gain of mineral in previously demineralized tissue. The word ‘remineralization’ can be misleading as it does not imply that the lesion has regained its original mineral content.”(Machiulskiene V et al. Caries Res. 2020;54(1):7-14) It particularly does not equate to ordered, structured crystal formations of hydroxyapatite, nor does it indicate the depth at which the mineral is deposited. 
 

Curodont Repair Fluoride Plus promotes the formation of enamel crystals throughout the lesion depth, helping preserve natural tooth structure and supporting the in-depth restoration of mineral density. Thus, the most accurate term to describe its mode of action is a non-invasive restorative intervention.

Superficial remineralizing treatments, such as fluoride varnish, are primarily indicated for the prevention of caries on sound tooth surfaces and early-stage decay just beneath the tooth surface. Fluoride is documented to have a depth of action of approximately 25 µm.( Schmidlin P et al. J Appl Oral Sci. 2016;24:31-6). 

Early-stage caries that extends beyond the tooth surface, deeper into the enamel, up to even the dentino-enamel junction, indicates that traditional prevention has failed. On proximal surfaces, this depth could be up to 1.5 mm (1500 µm) and on the occlusal surfaces up to 2-2.5 mm (2000-2500 µm). For such lesions, Curodont Repair Fluoride Plus is the drill-free treatment that enables the restoration of mineral density throughout the lesion depth. 

Caries is the most prevalent non-communicable disease worldwide.* Early-stage caries affect nearly 80% of all patients with approximately 3.5 lesions per patient. A majority of these lesions are left untreated. These untreated lesions can progress resulting in irreversible loss of tooth structure, accompanied by pain and swelling. Over time, more complex treatments may be required and can ultimately lead to tooth loss. Untreated cavities may also affect overall health, increasing the risk of secondary diseases. (Liu J et al. Int J Epidemiol. 2022;51:1291-1303) So far, there has been no targeted treatment tailored for these early-stage lesions. Curodont Repair Fluoride Plus closes this treatment gap. It is a one-time, proactive, drill-free and needle-free treatment that enables the restoration of mineral density throughout the depth of the lesion and preserves natural tooth structure. The entire procedure takes as little as 3 minutes, presenting a win-win situation for both clinicians and patients. 

* Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1789–8583   

Curodont Repair Fluoride Plus can be used for the treatment of early-stage carious lesions on all teeth and tooth surfaces.  

These lesions often appear as white spots (and, occasionally, brown) on smooth and occlusal surfaces. For proximal lesions, radiographs and/or advanced diagnostic measures, such as transillumination may be used. Early-stage caries seen on x-rays or seen as established white spot lesions indicate that traditional prevention has failed. Then, Curodont is the treatment that acts throughout the depth of lesions. 

The range of lesions that can be treated using Curodont Repair Fluoride Plus, according to common classification systems, include:   

i. E0-E2, D1-D3 notation system  

E1 and E2 lesions. D1 lesions may be treated, only if they are not cavitated.   
[Anusavice K. J Dent Educ. 2005;69:538-854.]   

 ii. WHO/Marthaler classification  

D1 and D2 lesions. D3 lesions may be treated only if they are not cavitated   
[Marthaler TM. Helv Odontol Acta 1966;10:1–18.]   

iii. ICDAS II scoring system.  

ICDAS Score 1 and score 2. Score 3 may be treated but the microcavity will not be filled. 

[https://iccms-web.com/uploads/asset/592848be55d87564970232.pdf. Accessed 01/02/2022]   

If frank cavitation is present, excavation of the caries and a conventional restoration with an artificial filling material is needed. Curodont Repair Fluoride Plus is not indicated for such lesions.   

Curodont Repair Fluoride Plus is suitable for all patients, including children (based on dentist’s supervision).

Yes. A high risk of caries is not a contraindication for the use of Curodont Repair Fluoride Plus. A study including high-risk preschool children demonstrated the efficacy of Curodont Repair Fluoride Plus in treating early-stage caries (Khairy et al. J Evid Based Dent Pract. 2025;25:102163). These patients are often recommended a regimen of regular recalls to diagnose new lesions as soon as they develop and treat these with Curodont Repair Fluoride Plus. 

Poor oral health is not a contraindication for the use of Curodont^TM Repair Fluoride Plus. There is no evidence indicating any difference in the results of Curodont Repair Fluoride Plus based on oral hygiene status. Maintaining good oral hygiene is a general guideline for everyone to prevent new disease and promote overall oral health.

Yes, Curodont^TM Repair Fluoride Plus can be used on early-stage caries developing around bonded brackets. Patients undergoing fixed orthodontic treatment are at an increased risk of developing caries, due to an increased difficulty in oral hygiene maintenance. Since the use of CRFP does not require the placement of a rubber dam or any finishing and polishing procedures, it can easily be used for such lesions without the need to remove the brackets.

Curodont Repair Fluoride Plus is a treatment for early-stage caries. It is not a preventive agent like toothpaste or fluoride varnish. When applied to the surface of early-stage caries, it penetrates beyond the tooth surface and into the full depth of the lesion to support the restoration of the mineral density throughout the depth of the lesion. Thus, it is not indicated for prevention but for early-stage caries, seen as white spots (or, occasionally, brown) on buccal and occlusal tooth surfaces or as radiolucencies in the enamel on interproximal surfaces on x-rays. 

Available evidence supports the use of Curodont Repair Fluoride Plus for early-stage caries on all tooth surfaces, including smooth and occlusal surfaces. 

One box of Curodont Repair Fluoride Plus contains 10x each of UNIT A (containing the CRFP sponge) and of UNIT B (droppers with the CRFP liquid). Each UNIT A sponge is meant to be saturated fully with one UNIT B dropper. Each fully saturated sponge can be used for one lesion.  

One lesion is defined as:  

• One interproximal site: Involving one or both surface(s)  

• One occlusal or smooth surface  

• One demineralized white spot lesion   

UNIT A and UNIT B must always be used together.

Scientific and real-world evidence has demonstrated that one application of Curodont Repair Fluoride Plus is sufficient to treat one lesion, with a success rate of over 90%. (Shaalan O et al. Clin Oral Investig. 2024;28:438)

1. Identify and diagnose early-stage carious lesions   
2. Patient education 
3. Product preparation – Squeeze out contents of one UNIT B into UNIT A receptacle to fully immerse the sponge.  
4. Professional oral prophylaxis 
5. Removal of organic debris and salivary pellicle (using your preferred method- prophy paste, pumice, air polisher).  
6. Rinse and dry.  
7. Etching using 35% phosphoric acid for not more than 20 seconds. [In interproximal sites, use unwaxed floss to distribute etchant] 
8. Rinse and dry.   
9. Ensure sponge is fully saturated and then place cotton rolls at the treatment site.    
10. Apply Curodont Repair Fluoride Plus by squeezing the sponge on/near the lesion surface for 5 seconds. (For interproximal sites, squeeze the sponge from the lingual and buccal embrasures. Separators or wedges are not required) 
11. The patient can close their mouth and is instructed to not eat, drink or rinse for 30 minutes after application.   
12. Discharge. Dispose used sponge/s and dropper/s.  
13. Regular recalls to diagnose new lesions and treat with Curodont Repair 

No advanced isolation techniques such as rubber dam are required in the clinical protocol of Curodont Repair Fluoride Plus. Basic aids such as cotton rolls around the treatment site are sufficient.   

Immediately after the application of Curodont Repair Fluoride Plus, the patient can close their mouth and should refrain from eating, drinking or rinsing for 30 minutes. Following treatment, routine oral hygiene measures including brushing twice a day and flossing are recommended. 

Curodont Repair Fluoride Plus has been safely and successfully used to treat over 3 million teeth in the USA (data on file). Clinicians should evaluate patients with known allergies when treating with CRFP. 

Yes, the entire procedure for CRFP takes as little as 3 minutes (including cleaning, etching and squeezing of the sponge on the lesion) and thus can be integrated into existing appointments by dentists and hygienists. Considering the high prevalence of early-stage caries, efficiencies can be further enhanced by including CRFP in all procedure trays such as those for routine hygiene, restorative, orthodontic, etc. Keeping patient education materials handy can also help clinicians with communication.

Success with Curodont Repair Fluoride Plus is seen as the stopping of the progression of the treated lesion and the restoration of mineral density throughout the depth of the lesion, with studies showing a success rate of over 90%.(Shaalan O et al. Clin Oral Investig. 2024;28:438) 

A recent study demonstrated that Curodont Repair Fluoride Plus led to a significant increase in mineral density throughout the lesion depth within only 2 weeks using Micro-CT and Scanning Electron Microscope analysis. [Cowen M et al. Biomater Res Rep 2025 Aug;175 Curodont™ Repair Fluoride Plus – Dental Advisor (Accessed 04/28/2026)] 

Due to the limitations of currently available diagnostic technologies in clinics, such as x-rays, the improved mineral density may not be immediately visible on x-rays.

There is no requirement to arrange definite follow–up appointments after treatment with CRFP. Patients can be recalled for their regular hygiene appointments as scheduled. Studies have shown a success rate of over 90% after one application of Curodont Repair Fluoride Plus.(Shaalan O et al. Clin Oral Investig. 2024;28:438) 

Curodont Repair Fluoride Plus is a non-invasive restorative treatment for early-stage caries. While esthetic improvement can occur as a result, Curodont is not intended to be a cosmetic treatment. It is recommended to treat early-stage caries as soon as they develop to maximize the esthetic improvement. In the esthetic zone, lesions treated with Curodont Repair Fluoride Plus can be supplemented with the topical application of the vVARDIS Enamel serum at home. 

Patient communication should be short, simple, and effective. For example: 

Situation: I’ve spotted some cavities on your x-rays. We can treat today with a drill-free solution, in as little as 3 minutes.  

Benefits: With this treatment, we can preserve your natural tooth structure. No needle, no drill. No artificial filling materials. 

How does it work:  Curodont™ works below the surface of the tooth to strengthen and repair damaged areas. 

It not only helps stop early decay from progressing, it supports the natural repair of the tooth – without needles, without drilling, and without traditional fillings. 

What about Fluoride? Fluoride can be used afterwards as Prevention against new cavities. For this cavity, prevention is already too late. because it is too deep for Fluoride to work. 

Any other option? Drilling. Today we know untreated caries can lead to severe diseases, when prevention is not an option anymore. 

What about insurance? Like any other procedure, some insurances reimburse, some don’t.  

But I am not feeling any pain? It is good that you are not feeling any pain. It means the cavity is not close to the dental pulp. Otherwise, we would be discussing more invasive procedures. 

During the follow-up appointment. 

Did it work (we cannot see on the X-ray)?  

In over 90% of cases, this treatment has been successful. It supports the restoration of new minerals throughout the entire cavity area. However, this process is not always visible on an X‑ray. 

If, at your next visit, we see that the cavity has not progressed, we know that this natural restoration process has begun — and the tooth does not need to be drilled at this stage. 

Curodont Repair Fluoride Plus is supported by clinical evidence corroborating a success rate of over 90% and in vitro evidence demonstrating in-depth hydroxyapatite formation. A few examples are as follows: 

1. A recently published in vitro study by Dental Advisor used MicroCT and Scanning Electron Microscopy (SEM) to evaluate the effect of one application of Curodont Repair Fluoride Plus on artificial carious lesions. Within only 2 weeks, a significant increase (p<0.001) in mineral density was seen throughout the depth of the lesions. SEM images showed bigger hydroxyapatite crystals than the untreated control (representing the initial state) with superficial areas already completely fused with sound enamel. [Cowen M et al. Biomater Res Rep 2025 Aug;175 Curodont™ Repair Fluoride Plus – Dental Advisor (Accessed 04/28/2026)] 
2. Shaalan et al. in an independent randomized controlled double blind compared Curodont Repair Fluoride Plus with 5% fluoride varnish enriched with calcium phosphate (FV).  

• At 3 and 6 months, Curodont demonstrated significantly greater reduction in lesion sizes compared with FV.  

• At 6 months, 100% of lesions showing reduction, complete reduction in 65.5% vs. only 13.8% with FV. 

• At 6 months, a 60% less risk of caries progression seen in CRFP-treated lesions compared to FV. 

      [Shaalan O et al. Clin Oral Investig. 2024;28:438]