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CurodontTM Repair
Fluoride Plus

Anticavity Dental Rinse

Biomimetic system for Guided Enamel Remineralization of early caries

– Professional product, for dental professionals only –

CURODONTTM Repair Fluoride Plus is a biomimetic, brush-on system that tackles early caries through Guided Enamel Remineralization.

Its patented formulation helps minerals diffuse into the tooth to remineralize and reharden the enamel, helping preserve the natural tooth structure.

Easy and fast application – Non-staining – Minimally invasive – For all surfaces – For all patients – One-time application.

1 box with 10 applicators can treat up to 30 lesions.


Darby Dental

Contact us for more information

Box contains 10 units of ready-to-use applicators.
One applicator can treat 1-3 lesions per patient.

In office

Sodium Fluoride, Water, Chlorhexidine diglucconate, Tromethamine, Trehalose Dihydrate, Oligopeptide-104, Hydroxypropyl Methylcellulose

In office

Visible Evidence

Remineralisation of a proximal caries lesion
Dr. Markus Schlee: Stomatologie 2014 (111); 175 – 181
Day 0
After six months
Occlusal caries
Dr. Frank Bröseler, 2012
Day 0
After six months
Visible “fading“ of the white spot lesion
Dr. Frank Bröseler: Broeseler, F. Et al. Clin Oral Invest 2020; 24: 123 – 132
Day 0
After six months


  • 10+ years in clinical practice
  • Over 100,000 successfully treated patients, with no side effects
  • More than 20 years of research
  • > 230 scientific peer-reviewed literature

Guided Enamel Remineralization

Guided Enamel Remineralization (GER) tackles initial carious lesions. GER bridges the gap between prevention and invasive restorative approaches. It enables effective therapy of initial caries and white spots through in-depth remineralization of the enamel, while still maintaining the integrity of the tooth.

Mode of Action

CurodontTM Repair Fluoride Plus brings fluoride where it is needed most – directly to early carious lesions and white spots. The formulation of the technology helps phosphate and calcium found in the saliva, to penetrate the enamel surface into the depth of the lesion. Lost enamel is re-hardened and remineralized over the following few weeks.
1. Natural caries protection In a healthy oral environment, saliva facilitates constant remineralization. Saliva is rich in calcium and phosphate. Fluoride actively supports this natural remineralization process and strengthens enamel.
2. Increased risk of caries The constant acid challenge from bacteria inhibits the natural remineralization cycle and tooth minerals are lost. If demineralization cannot be stopped, enamel becomes porous (i.e. white spots). Targeted anti-caries measures are needed.
3. CurodontTM Repair Fluoride Plus applied directly onto the cleaned surface of the white spot CurodontTM Repair Fluoride Plus acts where it is needed. Over the course of the weeks the application procedure help minerals, like fluoride and calcium, to penetrate the enamel surface into the white spots and to remineralize and re-harden the affected enamel over the next few weeks.

How to apply

The non-invasive therapy with CurodontTM Repair Fluoride Plus (CRFP) is as safe as its application is easy. The entire process of applying CRFP is completed within 8-10 minutes, without drilling, anesthesia, or pain.
  1. Perform oral prophylaxis and finish with a coarse prophy paste (with or without fluoride), pumice, or air polisher to eliminate all organic matter and the salivary pellicle. Unwaxed dental floss must be used to distribute prophy paste/pumice through the proximal surface.
  2. Rinse thoroughly and dry.
  3. Apply 35% phosphoric acid to the surface of the early carious lesion for 20 seconds and then rinse thoroughly. Unwaxed dental floss must be used to distribute it over the proximal surface.
  4. Isolate the treatment area (cotton rolls, dry angle, etc). The use of a rubber dam is not necessary.
  5. Activate the CURODONTTM REPAIR FLUORIDE PLUS applicator, remove the black clip, and plunge the sponge into the liquid reservoir. Let the sponge soak in the liquid for at least 10 seconds, then withdraw the saturated sponge.
  6. Squeeze the sponge on the treatment area to draw as much liquid as possible on/near the surface of the early carious lesion; a ‘painting’ motion is not recommended.
    *Important: Only the sponge applicator must be used. The solution cannot be transferred to other applicators.
  7. Wait for 5 minutes, using the saliva ejector as needed. Do not rinse during this time. The patient can semi-close his/her mouth if needed. Use this time to provide routine instructions and emphasize the need to maintain good oral hygiene.
  8. Discharge the patient, instructing them not to eat, drink, or rinse for 30 minutes.

For caries classification, please visit ADA or FDI

Smooth Surface

Application Video

Interproximal Surface

Application Video

Occlusal Surface

Application Video

Ortho Case

Application Video


Curodont Repair Fluoride Plus is a remineralizing, low-viscosity liquid material that induces Guided Enamel Remineralization in early, non-cavitated carious lesions (watch areas/white spot lesions). These lesions often appear as white spots on buccal and occlusal surfaces. For proximal lesions, which may not be visually accessible, radiographs and/or advanced diagnostic measures, such as laser fluorescence, fiber-optic transillumination, impedance measurement, etc. may be used.
In a majority of cases, one application of Curodont Repair Fluoride Plus is sufficient to treat one lesion, provided the patient maintains good oral hygiene in this period. The remineralization continues to increase thereafter. If deemed necessary by the clinician, such as in cases like rampant caries, the application may be repeated.
Natural enamel formation in primary and permanent teeth requires a few months to a few years, respectively. Curodont Repair Fluoride Plus is a biomimetic system that treats early caries by remineralizing enamel over time. The speed of remineralization depends on a number of patient behavioral and environmental factors, such as oral hygiene maintenance, quality of saliva, dietary habits, etc.
Sodium hypochlorite is an agent used frequently in dentistry to dissolve organic content. In the protocol for Curodont Repair Fluoride Plus (CRFP), 2% sodium hypochlorite is used, with a small cotton pellet and tweezers, to remove the salivary pellicle and any other organic deposit from the surface of the early carious lesions (watch areas/white spot lesions). This step ensures that the pores of this pseudo-intact surface layer are not blocked by any organic matter, in order to facilitate the effective diffusion of CRFP within the sub-surface body of the lesion.

Alternatives to sodium hypochlorite include air polisher, prophy paste, pumice etc. as mechanical means of removal of organic content and the salivary pellicle. If these alternative methods are used, it is important to rinse the tooth thoroughly after this step.

The use of 2% sodium hypochlorite may be a more ‘thorough’ way to remove the salivary pellicle and organic matter.

Yes, the use of fluoride varnish or any other remineralizing paste is permitted after the use of CRFP. These agents act as suppliers of calcium, phosphate, and/or fluoride ions to the CRFP technology within early carious lesions (watch areas/white spot lesions), thus supporting the Guided Enamel Remineralization.

When using these agents, they must be applied at least 5 minutes after the application of CRFP in-office or after the appointment, at home.

An ideal complement to Curodont Repair Fluoride Plus is Curodont Protect. This anti-cavity dental gel can be applied once a day for one week (or until the tube is finished) on a lesion that has been treated in-office with Curodont Repair Fluoride Plus.

No, the use of CRFP before the bonding of orthodontic brackets or around bonded orthodontic brackets does not affect the shear bond strength of adhesives used for bonding.
The active and inactive states of early caries are not well defined. A lesion can go from being active to inactive and vice versa and currently, there is no method to definitely determine if a lesion is 100% active or inactive. In such a scenario, taking into account all factors related to location and appearance of the lesion, it may be safer to treat all early carious lesions (watch areas/white spot lesions) with CRFP than to risk progression of the lesion.
With regards to treating a patient who needs both bleaching and treatment of early caries with CRFP, there is no strict requirement to do one before the other:
  1. If CRFP treatment is done first, it is recommended to wait 2 weeks before the bleaching treatment.
    After treatment with CRFP, the vVARDIS technology diffuses within the body of the early carious lesion (watch area/white spot lesion) and remineralization begins. A gap of 2 weeks between the CRFP treatment and the bleaching treatment is recommended, to maximize effectiveness of CRFP.
  2. If the bleaching is done first, CRFP can be used immediately.
    Peroxide, in addition to bleaching, ‘cleans up’ the tooth surface well and removes the need for the pre-treatment steps of salivary pellicle removal and etching before using CRFP. However, if a few days have passed after the bleaching, it is recommended to follow the entire protocol as per instructions. In fact, CRFP will also help tackle the demineralization occurring due to bleaching.

In the CRFP protocol, we suggest using unwaxed floss to effectively apply the phosphoric acid gel on proximal surfaces. There are two reasons for preferring unwaxed floss over waxed floss:

  1. Unwaxed floss is thinner than waxed floss and may slip through tighter contacts better. One of the purposes of waxed floss is the ease of movement on tooth surfaces due to the wax. However, in the present case, the etchant gel acts as a ‘lubricant’ for the unwaxed floss.
  2. Waxed floss is known to sometimes leave waxy residues on tooth surfaces. These residues run the risk of getting lodged in the pores of the surface of early caries (watch area/white spot lesion) and blocking them, which might interfere with the diffusion of the CRFP liquid through the lesion surface. Additionally, wax is hydrophobic (non-polar) while the CRFP solution is hydrophilic (polar); this difference in nature will also cause the wax to interfere with the diffusion of the solution.

CRFP is a treatment for early caries. The CRFP technology works by enabling the diffusion of remineralizing ions into the body of early carious lesions (watch areas/white spot lesions). Thus, it is not an appropriate product to use on intact tooth surfaces.

Curodont Protect, an anti-cavity dental gel, would be an ideal product for caries prevention, including for patients at high caries risk.

If early caries are detected on adjacent proximal surfaces, use one CRFP applicator for both lesions. The sponge must be squeezed, preferably with the help of a flat-ended instrument such as a composite instrument, through the lingual and buccal embrasures to deposit as much of the CRFP liquid near the surface of the early caries (watch area/white spot lesion) as possible. Keep area isolated for 5 minutes while the formula soaks in.
CRFP is a non-invasive, painless, and safe treatment for early caries that works by Guided Enamel Remineralization. The demineralized environment within early carious lesions provides the platform for the CRFP technology to work and current evidence does not indicate its use in white spots that have a non-bacterial etiology.

Whitening toothpastes depend on different mechanisms to achieve the whitening effect. Many toothpastes depend on hydroxyapatite for whitening, in which case, there is absolutely no issue with using it right after a Curodont Repair Fluoride Plus treatment. The hydroxyapatite may assist in the remineralizing action of Repair.

However, even if the whitening toothpaste is peroxide-based, it may be used post-CRFP application. The peroxide content in whitening toothpastes is fairly minimal and the ‘brushing’ action ensures that the contact time of the agent with the CRFP technology within early lesions will also be quite low. Thus, the probability of peroxide from these toothpastes interfering with the action of CRFP is very low.

In most cases, except when caries involves the outer third of dentin while the lesion is still non-cavitated, we would not recommend using CRFP.

CRFP works by enabling the diffusion of remineralizing ions, such as Ca2+ and F-, in early carious lesions. The pseudo-intact surface of the early enamel caries provides an ‘undisturbed compartment’ for the CRFP technology to ‘stay’ in and perform its action. Caries extending into dentin are complicated due to two factors:

  1. By the time caries extends into dentin, the tooth structure is often undermined enough to undergo a break down, converting the lesion into a cavity. A cavity is a contaminated area with degraded organic matrix, bacteria, food debris etc., all of which must be excavated before the tooth can be restored.
  2. The lack of an ‘intact’ surface layer in a cavitated lesion precludes the presence of an ‘undisturbed compartment’ for CRFP to stay in and work.
    Both these factors mean that cavitated lesions extending significantly into the dentin cannot be treated using CRFP.
  3. However, in cases where caries extending to the dentino-enamel junction or to the outer 1/3rd of dentin are still non-cavitated, CRFP can be used to treat these lesions.



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