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vVARDIS technology for remineralization of enamel

  1. Aggeli, A., M. Bell, et al. (2003). “pH as a trigger of peptide beta-sheet self-assembly and reversible switching between nematic and isotropic phases.” J Am Chem Soc 125(32): 9619-9628.
  1. Araujo, I.J. et al. (2019) “P11-4 self-assembly peptide induces biomineralization without cytotoxicity in MDPC-23 cell line” Pulp Biology and Regeneration Group Satellite Meeting, Portland OR, USA 23-25 June 2019
  1. Barbosa-Martins, L.F. et al (2018) “Biomimetic Mineralizing Agents Recover the Micro Tensile Bond Strength of Demineralized Dentin.” Materials Sep 14;11(9): pii: E1733. doi: 10.3390/ma11091733.
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  1. Davies, R.P.W. et al (2014). “Novel Self-Assembling Peptides, for the Treatment of Early Caries Lesions” Caries Res (48): (2014) 404.
  1. Davies, R.P.W. et al (2015). “Treatment of Fabricated Caries Lesions; Self-Assembling Peptides vs. Fluoride” Caries Res (49): 359
  2. De Sousa, J.P. et al (2019). “The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in Dentin.” J Dent Res https://10.1177/0022034518817351
  1. Doberdoli, D., et al (2019) “Efficacy of Self-assembling Peptide P11-4 with Fluoride Varnish or Self-assembling Peptide Matrix for the Treatment of Early Occlusal Carious Lesions” Oral Presentation 0368 at IADR 2019, Vancouver, Canada
  1. Felton, S. (2005): “Self Assembling β-sheet Peptide Networks as Smart Scaffolds for Tissue Engineering”. PhD Thesis, University of Leeds, Leeds Dental Institute.
  1. Firth, A., et al. (2006). “Biomimetic self-assembling peptides as injectable scaffolds for hard tissue engineering.” Nanomed (1): (2006) 189.
  1. Kang, J., et al. (2016). “Multi-level modelling to further understanding of micro-CT data”, Enamel 9 Conference, Leeds, UK.
  1. Kirkham, J., A. Firth, et al. (2007). “Self-assembling peptide scaffolds promote enamel remineralisation.” J Dent Res 86(5): 426-430.
  1. Kyle, S., A. Aggeli, et al. (2010). “Recombinant self-assembling peptides as biomaterials for tissue engineering.” Biomaterials 31(36): 9395-9405.
  1. Kyle, S., A. Aggeli, et al. (2008). “The self-assembling peptide, P11-4 for a scaffold in regenerative medicine.” Eur Cell and Materials 16(Suppl 3): 70.
  1. Maude, S., E. Ingham, et al. (2013). “Biomimetic self-assembling peptides as scaffolds for soft tissue engineering.” Nanomedicine (Lond) 8(5): 823-847.
  1. Saha, S., et al. (2019). “A biomimetic self-assembling peptide promotes bone regeneration in vivo: A rat cranial defect study” Bone 24 (127):602-611. doi: 10.1016/j.bone.2019.06.020
  1. De Sousa, J.P., Puppin-Rontani, R.M. et al. (2018) “The Self-Assembling Peptide P11-4 Prevents Collagen Proteolysis in Dentin” J Dent Res
  1. Wilshaw, S. P., A. Aggeli, et al. (2008). “In vivo assessment of the immunogenicity of self-assembling peptides for use in regenerative applications.” Eur Cell and Materials 16(Suppl 3): 97
  1. Alkilzy, M. et al (2018) “Self-assembling Peptide P11-4 and Fluoride for Regenerating Enamel.” J Dent Res (97): (2018) 148
  1. Barbosa-Martins, L. F. et al (2018) “Enhancing bond strength on demineralized dentin by pre-treatment with selective remineralising agents.» J Mech Behaviour Biomedical Materials
  1. Barbosa-Martins, L. F. et al (2018) “Biomimetic Mineralizing Agents Recover the Micro Tensile Bond Strength of Demineralized Dentin» Materials 2018, 11, 1733; doi:10.3390/ma11091733
  1. Bröseler, F. et al (2019) “Randomised clinical trial investigating self-assembling peptide P11-4 in the treatment of early caries.” Clin Oral Invest,
  1. Brigi, C. (2014) “In vitro measurement of dental remineralisation: investigating a biomimetic self-assembling peptide treatment strategy” Master Thesis, Queen Mary, University of London.
  1. Brubaker, L. et al. (2016) “Remineralization of Early-Enamel Lesions Using Biomimetic Regeneration Combined With Fluoride-toothpaste” AADR Abstract 1809, Los Angeles, USA.
  1. Brunton, PA., et al, (2013) “Treatment of early caries lesions using biomimetic self-assembling peptides – a clinical safety trial” Brit Dent J, 2013, 215: E6
  1. Davies, R.P.W. et al, (2015) “Treatment of Fabricated Caries Lesions; Self-Assembling Peptides vs Fluoride. Abstract 143” Caries Res (49): (2015): 359
  1. Doberdoli, D. et al (2020) “Randomized Clinical Trial investigating Self-Assembling Peptide P11-4 for Treatment of Early Occlusal Caries” Scientifc Rep https://doi:10.1038/s41598-020-60815-8
  1. Godenzi, D. (2018) “Give Teeth a Chance: Curodont Repair in daily practice” Lecture at EAPD, Lugano, Switzerland 2018
  1. Jablonski-Momeni, A. & Heinzel-Gutenbrunner M. (2014) “Efficacy of the “Self-assembling peptide P11-4” in the formation of a remineralization scaffold on artificially induced enamel lesions on smooth surfaces.” J Orofac Orthop, 75 (3): 175-190
  1. Jablonski-Momeni, A. et al (2020) “Impact of self-assembling peptides in remineralisation of artificial early enamel lesions adjacent to orthodontic brackets” Sci Rep 10, 15132 (2020)
  1. Kamal, D. et al (2018) “Comparative evaluation of remineralizing efficacy of biomimetic self-assembling peptide on artificially induced enamel lesions: An in vitro study” J Conserv Dent 21:536-41
  1. Kamal, D. et al (2020) ”Complementary remineralizing effect of self-assembling peptide (P11-4) with CPP-ACPF or fluoride: An in vitro study” J Clin Exp Dent 12(2): e161-8
  1. Kind, L., et al (2017) “Biomimetic Remineralization of Carious Lesions by Self-Assembling Peptide.” J Dent Res 96(7): 790-797.
  1. Kirkham, J., et al. (2007). “Self-assembling peptide scaffolds promote enamel remineralisation.” J Dent Res 86(5): 426-430.
  1. Knaup, T., et al (2020) “Effect of the caries-protective self-assembling peptide P11-4 on shear bond strength of metal brackets.” J Orofac Orthop
  1. Kobeissi, R. et al (2020) “Effectiveness of Self-assembling Peptide P11-4 Compared to Tricalcium Phosphate Fluoride Varnish in Remineralization of White Spot Lesions: A Clinical Randomized Trial.”Int J Clin Pediatr Dent. 2020;13(5):451-456. doi:10.5005/jp-journals-10005-1804
  1. Kucukyilmaz, E. et al. (2016) “Measuring the remineralization potential of different agents with quantitative light-induced fluorescence digital Biluminator” J Appl Biomater Funct Mater DOI: 10.5301/jabfm.5000317
  1. Moreira, KMS. et al (2021) “Impact of biomineralization on resin/biomineralized dentin bond longevity in a minimally invasive approach: An “in vitro” 18-month follow-up” Dental Materials
  1. Patel, S. et al. (2016). “In Vitro Assessment of a Novel Biomimetic-Regeneration of Early Caries Lesions.” AADR Abstract 1808, Los Angeles, USA.
  1. Schlee, M. et al. (2017). “Clinical performance of self-assembling peptide P11-4 in the treatment of initial proximal carious lesions: A practice-based case series.” J Invest Clin Dent: DOI: 10.1111/jicd.12286.
  1. Schlee, M. et al. (2014). “ Klinischer Effekt biomimetischer Mineralisation bei Approximalkaries.” Stomagologie 111(4-5):175-181.
  1. Schmidlin, P. et al. (2016). “In vitro re-hardening of artificial enamel caries lesions using enamel matrix proteins or self-assembling peptides.” J Appl Oral Sci 24(1):31-36
  1. Sedlakova Kondelova, P. et al (2020). “Efficacy of P11-4 for the treatment of initial buccal caries: a randomized clinical trial.” Sci Rep 10(1): 20211
  1. Sezici, Y., et al. (2021) “Comparative evaluation of fluoride varnishes, self-assembling peptide-based remineralization agent, and enamel matrix protein derivative on artificial enamel remineralization in vitro.” Prog Orthod. 22, 4 (2021).
  1. Silvertown JD, et al. (2017). “Remineralization of natural early caries lesions in vitro by P11-4 monitored with photothermal radiometry and luminescence.” J Invest Clin Dent. 017;00:e12257. doi:10.1111/jicd.12257.
  1. Sindhura, V. et al (2018). “Evaluation of enamel remineralizing potential of self-assembling peptide P11-4 on artificially induced enamel lesions in vitro.” J Indian Soc Pedod Prev Dent, 36(4) 352-356.
  1. Suda, S., et al. (2018). “Application of the Self-Assembling Peptide P11-4 for Prevention of Acidic Erosion” Operative Dentistry, DOI: 10.2341/17-175-L
  1. Takahashi, F. et al (2016). “Ultrasonic assessment of the effects of self-assembling peptide scaffolds on preventing enamel demineralization.” Acta Odontol Scand (74): 142-7
  1. Takahashi, H. et al (2016). “Evaluation of Application of Peptide P11-4 on Remineralization of Enamel.” AADR Abstract 1804, Los Angeles, USA.
  1. Takahashi, F. et al (2017). “Application of the Self-assembling Peptide P11-4 on Acid Erosion Prevention» IADR Abstract, San Francisco, USA
  1. Üstün, N. & Aktören, O. (2019). “Analysis of efficacy of the self-assembling peptide-based remineralization agent on artificial enamel lesions.” Microsc Res Tech DOI: 10.1002/jemt.23254.
  1. Welk, A. et al (2020). “Effect of self-assembling peptide P11-4 on orthodontic treatment-induced carious lesions.” Scientific Rep
  1. Ardu, S. et al (2018) “Protection Against Discolouration by Two Over-the Counter Desensitising Products” Oral Health Prev Dent 16(5) 439-444
  1. Bamidis, E. & Kunzelmann K.-H. (2017) “Evaluation of a Novel Hypersensitivity Relieve Gel Being Applied Prior to Bleaching” BSODR, Plymouth, GB
  1. Bilge K, Kılıç V. Effects of different remineralizing agents on color stability and surface characteristics of the teeth following vital bleaching. Microsc Res Tech. 2021 Oct;84(10):2206-2218. doi: 10.1002/jemt.23774.
  1. Ceci M. et al, (2015) “Effect of Self-Assembling Peptide P11-4 on Enamel Erosion: AFM and SEM Studies” Scanning (9999): 1-8.
  1. Chen X. et al, (2014) “In vitro Evaluation of Dentine Remineralisation by a Self-Assembling Peptide Using Scanning Electron Microscopy. Abstract 40” Caries Res (48): (2014) 402.
  1. Hill R. et al (2020) “An In Vitro Comparison of A Novel Self-Assembling Peptide Matrix Gel and Selected Desensitizing Toothpastes in Reducing Fluid Flow by Dentine Tubular Occlusion” J Dent Maxillofacial Res 3 (1) 1-11
  1. Jablonski-Momeni, A. et al. (2019) “Randomised in situ clinical trial investigating self-assembling peptide matrix P11-4 in the prevention of artificial caries lesions” Scientific Reports 9, Article number: 269
  1. Müller, P. et al. (2013) “Evaluation of a tooth gel with Curolox® Technology as part of professional tooth-cleaning, with regards to patient satisfaction and the effects of hypersensitivity” Swiss Dental Hygienists Conference 2013, Lausanne.
  1. Saxer, U.P. et al (2014) “Efficacy of CURODONT™ D’SENZ to reduce tooth sensitivity when applied before professional dental cleaning“ Internal Report.
  1. Schlee M., et al. (2018). “Self-Assembling Peptide Matrix for treatment of dentin hypersensitivity: A randomized controlled clinical trial” J Periodontol doi: 10.1002/JPER.17-0429.
  1. Soares, R. et al (2017) “Assessment of Enamel Remineralisation After Treatment with Four Different Remineralising Agents: A Scanning Electron Microscopy (SEM) Study” J Clin Diagn Res Vol-11(4): ZC136-ZC141
  1. Stoleriu, S. et al (2019) “ Study Regarding the Capacity of Self-assembling Peptides to Remineralize the Acute and Chronic Incipient Caries Lesions” Rev Chim (Bucharest) 70(8) 3073-307

Brightening and whitening with vVARDIS technology

  1. Bommer, C. et al (2018) “ Hydroxyapatite and Self-Assembling Peptide Matrix for Non-Oxidizing Tooth Whitening” J Clin Dent 2018;29:57–63
  1. Hojabri, N. (2019) “Evaluation of the Whitening Effect of a Mixture of Self-assembling Peptide and Hydroxyapatite on Bovine Enamel”, Thesis, LMU Munich
  1. Hojabri, N. et al (2020) “Adhesion and whitening effects of P11-4 self-assembling peptide and HAP suspension on bovine enamel.” Clin Oral Investig https://10.1007/s00784-020-03654-1
  1. Kunzelmann, K.-H. Lysek, D.A. (2015). “Working Mechanism of Tooth Whitening Based on Hydroxyapatite Suspended in a P11-4 Peptide Matrix.” IADR Abstract 838, Boston, USA.
  1. Xu, X. (2015). “New Approaches to Tooth Whitening Based on Changing the Optical Properties with Calcium Phosphate Containing Suspensions”, Thesis, LMU Munich
  1. Focus Group (2019). “Effectiveness and Reception of a novel non-peroxide whitening product as judged by consumers”, New York & Los Angeles, INTERNAL REPORT

Review articles

  1. Acharya, G. et al (2016). “Recent Biomimetic Advances in Rebuilding Lost Enamel Structure.” J Int Oral Health 8(4):527-535
  1. Alkilzy, M. et al (2018). “Treatment of Carious Lesions Using Self-Assembling Peptides.” Adv Dent Res 29(1): 42-47.
  1. Alkilzy, M. & Splieth, C.H. (2020). “Self-assembling peptides for caries prevention and treatment of initial carious lesions, a review.” Dtsch Zahnärztl Z Int 2(1): 21-25
  1. Amaechi, B. T. (2015). “Remineralization therapies for initial caries lesions.” Current oral Health Reports 2(2): 95-101
  1. Amaechi, B. T. (2017). “Remineralization – the buzzword for early MI caries management.” Br Dent J 223(3): 173-182
  1. B K A, R Y, Puranik MP. (2022) Remineralization of early enamel caries lesions using self-assembling peptides P11-4: Systematic review and meta-analysis. J Oral Biol Craniofac Res. 12(3):324-331. doi: 10.1016/j.jobcr.2022.03.012
  1. Bonchev, A. et al (2020). “Self-assembling Peptide P 11-4: A Biomimetic Agent for Enamel Remineralization” Int J Pept Res Ther
  1. Buzalaf, M. A. & Pessan, J. P. (2017). “New Preventive Approaches Part I: Functional Peptides and Other Therapies to Prevent Tooth Demineralization» Monogr Oral Sci 26: 88-96
  1. Clarkson, B. H. & Exterkate, R. A. M. (2015). “Noninvasive dentistry: a dream or reality?” Caries Res 49 Suppl1: 11-17
  1. Donovan, T. E. et al. (2014). “Annual review of selected scientific literature: report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry.” J Prosthet Dent 112(5): 1038-87
  1. Gonzalez-Cabezas, C. & Fernadez, C.E., (2018) “Recent Advances in Remineralization Therapies for Caries Lesions” Adv Dent Res 29(1) 55-59
  1. Mohamed RN et al. (2021) Self-assembling peptide P11-4 in remineralization of enamel caries – a systematic review of in-vitro studies. Acta Odontol Scand 79(2):139-146. doi: 10.1080/00016357.2020.1825799
  1. Pandya, M. & Diekwisch, T. (2019) «Enamel biomimetics-fiction or future of dentistry” Int J Oral Sci 11(1) 8
  1. Philip, N. (2018). “State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management.” Caries Res 53: 284-295
  1. Pitts, N. (2013). “Summary of: Treatment of early caries lesions using biomimetic self-assembling peptides – a clinical safety trial.“ Br Dent J 2015(4): 174-175